Antigens, Lymphoid Cells and the Immune Response by G. J. V. Nossal

By G. J. V. Nossal

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The distribution of injected flagellar antigens between the organs of conventionally raised rats is influenced by opsonins. Some idea of the extent of influence of opsonins in the pattern of distribution has been gauged using three different approaches, in each of which an absence or diminution of opsonins is presumed to occur; ( 1 ) The use of germfree rats. (2) X-irradiation of rats. (3) Chronic thoracic duct lymph drain­ age of rats. Details of the histological localization pattern of flagellar antigens will be given later (Chapter 7 ) ; here the effect on organ dis­ tribution is briefly reported.

There is general agreement on the marked inhibition which passively transferred IgG can induce. There is still some uncertainty about the effects caused by transferred IgM. 36 3. Antibodies and the Afferent Limb There is httle information on the detailed mechanism whereby anti­ body suppressed the antibody response. Dixon et al. (1967) did not observe a direct adverse effect of passively administered antibody on potentially responsive cells. Rather, the close parallelism between the amount of passive antibody needed to suppress the subsequent antibody response and the size of the antigenic challenge suggested that the pas­ sive antibody acted by neutralizing the effect of retained antigen.

Many workers have studied the eflFects of iodination on the properties of proteins (frequently serum proteins) as revealed either by the be­ havior of the iodinated protein in serological tests or by the survival of the protein in the blood after intravenous injection. Provided the extent of substitution of the protein was about 1 gm atom of iodide per 30,000 gm of protein or less, it was generally found that the prop­ erties of the protein were unchanged. Also, such trace-labeled proteins were found to behave similarly to unlabeled protein after intravenous 40 4.

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