Apoptosis in Hormone-Dependent Cancers by G. Aumüller, P. M. Holterhus, W. Eicheler (auth.), Martin

By G. Aumüller, P. M. Holterhus, W. Eicheler (auth.), Martin Tenniswood, Horst Michna (eds.)

It is now broadly accredited that cells be ready to begin a software of gene-directed loss of life, a method known as "apoptosis" that may even be used as an leading edge process for healing intervention in melanoma treatment. specialists during this region document at the law and regulate of apoptosis in hormone established (neoplastic) tissue and the prospect to use lively phone dying for healing application.

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Proliferation Marker Ki-67 (MIB-1 Monoclonal Antibody). Consistent labeling was achieved only in formaldehyde-fixed fresh cystoprostatectomy specimens (bladder cancer) after extensive microwave treatment (up to 7 cycles) and prolonged antibody incubation. 1% and, exceptionally, 1%. Surprisingly, phases of increased growth were not reflected in the labeling density. A few basal and adluminal cells were stained in fetal, infantile, and pubertal glands, but this was very rare. As there are considerable differences in the onset of maturation, the respective proliferative steps may be lacking in our relatively small series of pubertal specimens.

Detection of Apoptosis in LNCaP Cell Cultures . . . . . . . . Miscellaneous . . . . . . . . . . . . . . . . . . . . . Results and Discussion . . . . . . . . . . . . . . . . . . Development of Human Prostate Tumor Xenograft Models . . . Properties of the Established Human Prostate Xenografts ....... Cell Death in the PC-82 and PC-EW Tumor Models . . . . . . Expression of Some Cell Death-Related Gene Products in Prostate Xenografts .

BGlandular differentiation. No growth in female mice, continued growth after androgen depletion. 1977 1981 1981 1982 1990 1990 1991 1991 1991 1991 1992 Origin Tumor model Established Table 1. Main characteristics of a panel of 11 human prostatic carcinoma xenografts ~ $2. CD

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