Bioaccumulation - New Aspects and Developments by B. Beek

By B. Beek

The bioaccumulation of endocrine disruptors, power natural chemical compounds and different compounds of excessive environmental influence has turn into of accelerating curiosity in latest environmental learn, hazard research and toxicology. This quantity provides an updated evaluate and introduces the reader to the hot inspiration of "internal impression focus" linking bioaccumulation and biomagnification within the nutrition chain to ecotoxicology and chance evaluation.

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Examples of synthetic estrogens are diethylstilbestrol (DES), hexestrol, dienestrol, 17a-ethinylestradiol, and mestranol. Synthetic androgens used in therapy are 17a-methyltestosterone, methandrostenolone, fluoxymesterone, methyltrienolone etc. Synthetic compounds with antiandrogenic activity are cyproterone acetate, flutamide and its metabolite 2-hydroxyflutamide. (iii) Endocrine-disrupting chemicals (contaminants, compounds) (EDCs) are also named endocrine disrupters (EDs) or xenohormones. S.

172]. h Range of BCF values of PCP in mussels and different fish species compiled from the literature by Geyer et al. [173a]. W i Mean BCF value calculated by Geyer et al. [173a]. L j Tetrabromobisphenol-A showed no estrogenic effects in an eucaryotic test system (K. Rehmann personal communication 1996). However, Körner et al. [138a] found estrogenic potency of this chemical in the proliferation assay with the MCF-cell line (purity of TBBA: 97%). k Relative binding affinity (RBA) assay in serum-free medium determined by Nagel et al.

The natural female steroid hormone with the greatest estrogenic activity is 17ß-estradiol. It is important to note that some synthetic estrogens, such as diethylstilbestrol (DES), moxestrol, and 11b-chloromethyl estradiol show 10 times more estrogenic activity than 17b-estradiol in the E-SCREEN assay [136]. Ethinylestradiol has the same estrogenic activity as 17b-estradiol, whereas the activity of the synthetic EDCs is by some orders of magnitude lower [136]. In this context it is important to note that most, if not all, efflu- Bioaccumulation and Occurrence of Endocrine-Disrupting Chemicals (EDCs) 37 ents of sewage treatment plants [145 b] and some rivers [145 c] in the United Kingdom are estrogenic to fish.

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