Calreticulin by Marek Michalak Ph.D. (auth.)

By Marek Michalak Ph.D. (auth.)

This ebook is set calreticulin, a multifunctional calcium binding protein first came across over two decades in the past. The protein has been defined in numerous destinations: endoplasmic reticulum, nuclear envelope, cytoplasmic granules, nucleus, cellphone floor or even secreted into the blood movement. This quantity outlines the newly found services for calreticulin together with its keep an eye on of calcium homeostasis, modulation of steroid-sensitive gene expression, regulate of viral RNA replication, modulation of nuclear delivery, function in T lymphocyte activation and cytotoxic killing, chaperone functionality, keep watch over of adhesion-dependent signaling through integrins, attainable position within the biology of ticks, within the pathology of autoimmune ailments and in blood function.

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Cell Regul 1991; 2:271-83. 47. Marcantonio EE, Guan JL, Trevithick JE et al. Mapping of the functional determinants of the integrin beta 1 cytoplasmic domain by site-directed mutagenesis. Cell Regul 1990; 1:597-604. 48. Freed E, Gailit J, Van der Geer P et al. A novel integrin beta subunit is associated with the vitronectin receptor alpha subunit (alpha v) in a human osteosarcoma cell line and is a substrate for protein kinase C. EMBO J 1989; 8:2955-65. 49. Aneskievich BJ, Haimovich B, Boettiger D.

Jorgensen (Department of Anatomy and Cell Biology, University of Toronto). The rat pigment epithelial cell line was a generous gift of Dr. E. Rodriguez-Boulan (Department of Cell Biology and Anatomy, Cornell University). O. REFERENCES 1. Ostwald TJ, MacLennan DH. Isolation of a high affinity calcium binding protein from sarcoplasmic reticulum. J Bioi Chern 1974; 249:974-9. 2. Fliegel L, Burns K, Opas M et al. The high-affinity calcium binding protein of sarcoplasmic reticulum. Tissue distribution, and homology with calregulin.

43. Wada I, Rindress D, Cameron P et al. SSRa and associated calnexin are major calcium binding proteins of the endoplasmic reticulum membrane. J Bioi Chern 1991; 266:19599-19610. 44. De Virgilio C, Biirckert N, Neuhaus J-M et al. CNE1, a Saccharomyces cerevisiae homologure of the genes encoding mammalian calnexin and calreticulin. Yeast 1993; 9:185-188. 45. Parlati F, Dominigues M, Bergeron JJM et al. Saccharomyces cerevisiae CNE1 encodes an endoplasmic reticulum (ER) membrane protein with sequence similarity to calnexin and calreticulin and functions as a constituent of the ER quality control apparatus.

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