By Alwin Krämer, Harald Löffler
This booklet offers an updated and thorough review of melanoma of unknown basic, encompassing issues starting from epidemiology, tumor biology, and prognostic components via to the latest diagnostic and healing advances. All elements of administration are lined, together with radiological, nuclear drugs, and pathological analysis, site-specific remedies, platinum-based blend chemotherapy, radiotherapy, and novel detailed remedies. transparent tips is out there on analysis of the tissue of beginning by way of gene expression and micro-RNA analyses and its healing implications. special instructions also are supplied at the identity of subsets of sufferers with a extra favorable analysis, in whom particular remedy bargains the opportunity of long term survival or perhaps healing. Readers will locate melanoma of Unknown basic to be a great resource of virtually orientated details that would help in supply of the very best deal with sufferers with this not easy diagnosis.
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Additional resources for Cancer of Unknown Primary
Eng. 2 Epidemiology, Risk Factors, and Survival in CUP: Pointers to Disease Mechanisms 25 46. Bissell MJ, Hines WC. Why don’t we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nat Med. 2011;17(2011):320–9. PubMed Epub 2011/03/09. Eng. 47. Stella GM, Senetta R, Cassenti A, Ronco M, Cassoni P. Cancers of unknown primary origin: current perspectives and future therapeutic strategies. J Transl Med. 2012;10:12. PubMed Epub 2012/01/26. Eng. 48. Greco FA, Lennington WJ, Spigel DR, Hainsworth JD.
Int J Cancer. 2013;133(5):1268–9. PubMed Epub 2013/02/13. Eng. 9. Greco FA, Pavlidis N. Treatment for patients with unknown primary carcinoma and unfavorable prognostic factors. Semin Oncol. 2009;36:65–74. PubMed Epub 2009/01/31. Eng. 10. van de Wouw AJ, Janssen-Heijnen ML, Coebergh JW, Hillen HF. Epidemiology of unknown primary tumours; incidence and population-based survival of 1285 patients in Southeast Netherlands, 1984–1992. Eur J Cancer. 2002;38:409–13. PubMed Epub 2002/01/31. Eng. 11. Hemminki K, Bevier M, Hemminki A, Sundquist J.
Hemminki K, Riihimaki M, Sundquist K, Hemminki A. Site-specific survival rates for cancer of unknown primary according to location of metastases. Int J Cancer. 2013;133(1):182–9. PubMed Epub 2012/12/13. Eng. 30. Hemminki K, Bevier M, Sundquist J, Hemminki A. Site-specific cancer deaths in cancer of unknown primary diagnosed with lymph node metastasis may reveal hidden primaries. Int J Cancer. 2013;132:944–50. PubMed Epub 2012/06/26. Eng. 31. Riihimaki M, Thomsen H, Hemminki A, Sundquist K, Hemminki K.