Cardiac Mechanotransduction by Matti Weckström M.D., Ph.D., Pasi Tavi Ph.D. (auth.)

By Matti Weckström M.D., Ph.D., Pasi Tavi Ph.D. (auth.)

For approximately hundred years the research of center body structure has had one important tenet, the "law" of Frank and Starling. This connects the go back of blood into the center and the blood strain with cardiac con­ traction strength. The "law" does it in a manner that allows the cardiovascular approach to react to perturbations with out significant malfunctions. This booklet is a compilation of stories of sought after scientists in this topic. The vary­ ence of the unique formula of the Frank-Starling precept is that mechanotransduction is the valuable subject matter that leads the reader throughout the e-book. because the discovery of the "law" the scope of themes relating to this topic has broadened vastly, as could be obvious simply through glancing on the contents of this ebook. Mechanotransduction within the center has many faces that variety from molecules to people and their illnesses. We editors desire that the massive volume of data compressed into the book's chapters varieties a balanced remedy and that the textual content is well approached via all who need to know what cardiac mechanotransduction is ready. Matti Weckstrom and Pasi Tavi Oulu, Finland June sixteen. 2006 Ackno^vledgments The editors are thankful to all authors for his or her remarkable contributions and for his or her persistence in the course of compiling this publication. This paintings used to be supported by way of the college of Oulu, the Biocenter Oulu and the Academy of Finland.

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73. Belus A, White E. Streptomycin and intracellular calcium modulate the response of single guinea-pig ventricular myocytes to axial stretch. J Physiol (Lond) 2003; 546:501-509. 74. Belus A, White E. Effects of streptomycin sulphate on Ica-L' ^Kr and IKS in guinea-pig ventricular myocytes. Eur J Pharmacol 2002; 445:171-178. 75. Pdrez-Miles F, Lucas SM, da Silva Jr PI et al. Systematic revision and cladistic analysis of Theraphosinae (Araneae: Theraphosidae). Mygalomorph 1996; 1:33-68. 76. Chen Y, Simasko SM, Niggel J et al.

Sachs F. Mechanical transduction in biological systems. Crit Rev Biomed Eng 1988; 16:141-169. 32. Sokabe M , Sachs F, Jing Z Q . Quantitative video microscopy of patch clamped membranes stress, strain, capacitance, and stretch channel activation. Biophys J 1991; 59:722-728. 33. Ruknudin A, Sachs F, Bustamante J O . Stretch-activated ion channels in tissue-cultured chick heart. Am J Physiol Heart Circ Physiol 1993; 2 6 4 : H 9 6 0 - H 9 7 2 . 34. Sato R, Koumi S. Characterization of the stretch-activated chloride channel in isolated human atrial myocytes.

Evidence for involvement of SAC in arrhythmias arising from brief stretch was first provided by Hansen et al,^^^ who demonstrated in isolated canine hearts that increasing left ventricular volume for 50 ms elicits ectopy that is blocked by 1-10 jlM Gd^^ but not by Ca ^ channel blockers. ^^^ Gd^^ also blocks delayed afcerdepolarizations in atria, ^ i n h i b i t s atrial fibrillation, ^ and minimizes dispersion of ventricular repolarization ^'^^ during pressure overload. "^^ GsMTx4 suppresses both atrial fibrillation induced by elevated intra-atrial pressure"^^ and spontaneous depolarizations and runs of tachycardia in ventricular myocytes isolated from an aortic regurgitation model of heart failure.

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