Case files. / Pathology by Eugene C Toy

By Eugene C Toy

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Eds. Harrison’s Principles of Internal Medicine, 16th ed. New York: McGraw-Hill, 2004:1746–62. Liu C, Crawford JM. The gastrointestinal tract. In: Kumar V, Assas AK, Fausto N, eds. Robbins and Cotran Pathologic Basis of Disease, 7th ed. Philadelphia, PA: Elsevier Saunders, 2004:804–9, 816–27. This page intentionally left blank ❖ CASE 3 A 57-year-old man presents with fatigue for several months and has noticed recently that the waistbands of his pants are tight in spite of a 15-lb weight loss.

C. D. E. 1] A. Hereditary nonpolyposis colorectal carcinoma, also known as Lynch syndrome, presents as an autosomal dominant disorder characterized by the formation of colon cancer, usually early in life. The disorder is associated with the hereditary nonpolyposis colorectal cancer gene and with the formation of multiple colonic polyps, although fewer than seen in the family adenomatous polyposis syndrome. 2] D. The presence of dysplastic epithelium within a colonic polyp defines adenomas of the colon, the three types of which are tubular adenomas, mixed tubulovillous (villoglandular) adenomas, and villous adenomas.

Pyloric stenosis may be acquired in adults with chronic antral gastritis or peptic ulcers near the pylorus. Other causes of acquired pyloric stenosis include gastric carcinomas, lymphomas, and adjacent carcinomas of the pancreas. Gastritis: Inflammation of the gastric mucosa. The inflammation may be predominantly acute, with neutrophilic infiltration, or chronic, with a predominance of lymphocytes and plasma cells. The classification and pathogenesis of acute and chronic gastritis are discussed below.

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